- 1896
- Born on September 1 in Weferlingen, near Helmstedt, to the pharmacist Karl Josef Emil Peiffer and his wife Anna, née Kux.
- 1903
- Death of his father.
- 1906
- His mother takes Dr. phil. Heinrich Watenphul as her second husband, schoolmaster of the Quedlinburg Gymnasium.
- 1911
- The family moves to Hattingen, where Dr. Watenphul is named director of the Realgymnasium.
- 1914
- Abitur (university entrance) examination. After initially studying medicine in Bonn, he chooses to study law in Strasbourg, Frankfurt am Main, and Munich. While in Munich, he first encounters contemporary art and makes the acquaintance of Paul Klee.
- 1918
- He takes his doctorate in church law in Würzburg, then does military service.
- 1919
- Law clerk at the Hattingen district court. He takes on the double name Peiffer Watenphul from September 4 on. In that autumn, he resolves to give up the legal profession and become an artist.
- 1919–22
- Student at the Bauhaus in Weimar; friendship with Lily and Paul Klee, Oskar Schlemmer, Josef Albers, Wassily Kandisky, Kurt Schwitters, and Johannes Itten.
- 1920
- Becomes a member of the artist group Das Junge Rheinland. Friendship with Otto Dix, Werner Gilles, and Otto Pankok. Under contract with Galerie Flechtheim in Düsseldorf. First visit to Salzburg.
- 1921
- Exhibition at the Städtisches Kunstmuseum, Essen, organized by Ernst Gosebruch. Travels to Italy in the autumn.
- 1922
- Works over the summer at the enamel workshop of Maria Cyrenius in Salzburg. Meets Alexej von Jawlensky in Elberfeld.
- 1924
- Travels to Mexico on July 1 (and remains there until February 1925).
- 1925/26
- Spends periods of time in Dalmatia, the south of France, Paris, Florence, and Rome.
- 1927
- Teacher of general artistic design at the Folkwangschule Essen (until 1931). Numerous trips to Paris.
- 1931
- Awarded the Prize of Rome. Nine-month residency at the Villa Massimo in Rome begins October 1.
- 1933
- Receives the Carnegie Prize.
- 1933–37
- Resides at the house of his parents in Hattingen, and also spends several periods in Italy.
- 1937
- Confiscation of his works in museums. Represented at the “Degenerate Art” exhibition in Munich. Moves to Italy that fall.
- 1937–41
- On Ischia with the painters Werner Gilles, Rudolf Levy, Hans Purrmann, Karli Sohn-Rethel, and Eduard Bargheer, the composer Gottfried von Einem, and others.
- 1941
- He is, from April on, teacher of drawing and painting at the Höhere Fachschule für textile Flächenkunst (Upper Professional School for Two-Dimensional Textile Art) in Krefeld.
- 1943
- His studio is destroyed by the bombing of Krefeld on June 22. He begins teaching at the Kunstgewerbeschule (School of Arts and Crafts) in Salzburg on September 1.
- 1946
- After the end of the war, he is refused a residency permit in Austria. He flees on foot over the Brenner Pass to Venice, where he lives with his sister Grace until 1958. Friendship with Filippo De Pisis, Zoran Mušič, and Peggy Guggenheim.
- 1950
- Four paintings shown at the XXVth Biennale in Venice.
- 1951
- First postwar trip to Salzburg. Studio at the Künstlerhaus (until 1971).
- 1952
- At the urging of the Zurich gallerist Chichio Haller, he prints his first color lithographs.
- 1956
- Travels to Spain and Morocco.
- 1958
- Moves to Rome (Via dei Greci).
- 1961
- First travels to Greece.
- 1964
- Begins his annual stays on the island of Corfu. Accepts a position at the International Summer Academy for Fine Arts in Salzburg. Is named a member of the Bavarian Academy of Fine Arts. Receives the Ring of Honor of the City of Salzburg.
- 1968
- Receives the Grand Federal Cross of Merit of the Federal Republic of Germany.
- 1970
- Paints his last painting in December, after which he does only drawings, watercolors, and lithographs.
- 1976
- Dies on July 13 in Rome. Buried in the cemetery at the Pyramid of Cestius.